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Drug dependence is a chronic relapsing brain disorder characterized by neurobiological changes that lead to a compulsion to take a drug with loss of control over drug intake. Abused drugs (cannabinoids, opioids, ethanol, nicotine and psychostimulants) by interacting with various neural pathways in brain induces pleasant state and responsible for relapses. All abused drugs have common property of elevating dopamine levels in nucleus accumbens...

Singh J, et al. FIGHTING DRUG DEPENDENCE BY BLOCKING CANNABINOID TYPE 1 RECEPTORS