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Antibodies to Cholesterol

Antibodies to Cholesterol,10.1073/pnas.85.6.1902,Proceedings of The National Academy of Sciences,G. M. Swartz

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Antibodies to Cholesterol   (Citations: 32)
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Journal: Proceedings of The National Academy of Sciences - PNAS , vol. 85, no. 6, pp. 1902-1906, 1988
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    • ...Indeed, in studies carried out by Matyas et al. (12), antibodies against squalene were elicited in mice only when squalene was formulated within liposomes containing endotoxin (lipid A). These data are in agreement with those previously reported showing that antibodies against cholesterol could be induced after immunization of mice with cholesterolloaded liposomes containing lipid A (18)...

    Giuseppe Del Giudice, et al. Vaccines with the MF59 Adjuvant Do Not Stimulate Antibody Responses ag...

    • ...Monoclonal anti-cholesterol antibodies (ACHAs) were first reported in 1988 by Swartz et al. (1) after immunizing mice with cholesterol-containing liposomes, together with lipid A as adjuvant...
    • ...They found cholesterol to be a surprisingly excellent immunogen, and murine monoclonal IgM-type complement-fixing antibodies to cholesterol were easily obtained (1)...
    • ...Several IgMs specific to cholesterol had already been generated and characterized (1, 4, 19); therefore, we focused our investigations on the IgGs...

    Adrienn Biro ´, et al. Novel anti-cholesterol monoclonal immunoglobulin G antibodies as probe...

    • ... binding and C activation by liposomes and their in vivo pulmonary vasoactivity? Among the various liposome preparations, we studied liposome-encapsulated hemoglobin (LEH) to evaluate the safety of this potential red blood cell substitute (27) and liposomes containing 71 mol% cholesterol (Chol), which were previously used in our laboratory as efficient activators of C (3) and inducers of anticholesterol antibodies in animals (5, 32)...
    • ...High-Chol LMV were also applied as efficient inducers of anti-Chol antibodies in mice (32) and rabbits (5)...

    JANOS SZEBENI, et al. Liposome-induced pulmonary hypertension: properties and mechanism of a...

    • ...Our findings substantiate the existence of antibodies that specifically recognize organized arrays of cholesterol (17)...

    Howard S. Kruth, et al. Monoclonal antibody detection of plasma membrane cholesterol microdoma...

    • ...In addition, several laboratories have produced polyclonal and monoclonal antibodies against cholesterol by injection of cholesterol-loaded liposomes or cholesterol crystals (Swartz et al., 1988; Perl-Treves et al., 1996; Kessler et al., 1996; Dijkstra et al., 1996; Bíró et al., 2007)...
    • ...Monoclonal antibodies against cholesterol werefirst isolated by Swartz et al. (1988)...
    • ...They compared the binding specificity of the polyclonal antibodies with a monoclonal antibody (2C5-6) reported by Swartz et al. (1988), and showed that the antibodies are similar to each other (Dijkstra et al., 1996) in that they both recognize cholesterol and structurally related sterols containing a 3β-hydroxyl group...

    Yoshiko Ohno-Iwashita, et al. Cholesterol-Binding Toxins and Anti-cholesterol Antibodies as Structur...

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