Prognostic Factors in Stereotactic Body Radiotherapy for Non–Small-Cell Lung Cancer,10.1016/j.ijrobp.2009.12.022,International Journal of Radiation On

Prognostic Factors in Stereotactic Body Radiotherapy for Non–Small-Cell Lung Cancer (Citations: 2)


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Purpose: To investigate the factors that influence clinical outcomes after stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer (NSCLC). Methods and Materials: A total of 101 consecutive patients who underwent SBRT with 48 Gy in 4 fractions for histologically confirmed Stage I NSCLC were enrolled in this study. Factors including age, maximal tumor diameter, sex, performance status, operability, histology, and overall treatment time were evaluated with regard to local progression (LP), disease progression (DP), and overall survival (OS) using the Cox proportional hazards model. Prognostic models were built with recursive partitioning analysis. Results: Three-year OS was 58.6% with a median follow-up of 31.4 months. Cumulative incidence rates of LP and DP were 13.2% and 40.8% at 3 years, respectively. Multivariate analysis demonstrated that tumor diameter was a significant factor in all endpoints of LP, DP, and OS. Other significant factors were age in DP and sex in OS. Recursive partitioning analysis indicated a condition for good prognosis (Class I) as follows: female or T1a (tumor diameter {<=}20 mm). When the remaining male patients with T1b-2a (>20 mm) were defined as Class II, 3-year LP, DP, and OS were 6.8%, 23.6%, and 69.9% in recursive partitioning analysis Class I, respectively, whereas these values were 19.9%, 58.3%, and 47.1% in Class II. The differences between the classes were statistically significant. Conclusions: Tumor diameter and sex were the most significant factors in SBRT for NSCLC. T1a or female patients had good prognosis.

Journal: International Journal of Radiation Oncology Biology Physics - INT J RADIAT ONCOL BIOL PHYS , vol. 79, no. 4, pp. 1104-1111, 2011

DOI: 10.1016/j.ijrobp.2009.12.022

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Prognostic Factors in Stereotactic Body Radiotherapy for Non–Small-Cell Lung Cancer,10.1016/j.ijrobp.2009.12.022,International Journal of Radiation On

References (37)

Cancer Statistics, 2009 (Citations: 1411)

Treatment of Non-small Cell Lung Cancer Stage I and Stage II: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) (Citations: 56)

Radiotherapy for patients with medically inoperable stage I nonsmall cell lung carcinoma: Smaller volumes and higher doses-A review (Citations: 55)

Stereotactic High Dose Fraction Radiation Therapy of Extracranial Tumors Using An Accelerator: Clinical experience of the first thirty-one patients (Citations: 145)

Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: A preliminary experience (Citations: 82)

Citations (2)

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