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Arrhythmogenic Substrate of the Pulmonary Veins Assessed by High-Resolution Optical Mapping

Arrhythmogenic Substrate of the Pulmonary Veins Assessed by High-Resolution Optical Mapping,10.1161/01.CIR.0000058461.86339.7E,Circulation,R. Arora

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Arrhythmogenic Substrate of the Pulmonary Veins Assessed by High-Resolution Optical Mapping   (Citations: 136)
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Journal: Circulation , vol. 107, no. 13, pp. 1816-1821, 2003
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    • ...Tissue was from same dog as in Figure 1. A, Low-power (4) view of PAS-stained slide...

    Chung-Chuan Chou, et al. Intracellular Calcium Dynamics and Anisotropic Reentry in Isolated Can...

    • ...Experimental studies [6-8] have demonstrated that the focal discharges may trigger multiple wavelet reentry...
    • ...A tight coupled single extrastimulus can result in unidirectional conduction block and may also result in a rapid reentrant circuit maintained in the atria [7]...
    • ...The results are in accord with experimental and clinical studies [6;7], which have shown the role of focal activation in the initiation of reentrant mechanisms, initiated by triggers located mainly in the left PVs...

    C. Tobon, et al. Vulnerability for reentry in a three dimensional model of human atria:...

    • ...This hypothesis was questioned by Haïssaguerre et al. [2] when demonstrating that atrial rapid paces originated within or in the ostium of the pulmonary veins (PVs) could act like triggers and, in some cases, they are responsible for the maintenance of AF. A tight coupled single extrastimulus in PVs can result in unidirectiona l conduction block and may also result in a rapid reentrant circuit maintained in the atria [3]...
    • ...This result is accord with experimental and clinical studies [3,11], which have shown the role of focal...

    C. Tobon, et al. Effect of the ectopic beats location on vulnerability to reentries in ...

    • ...The PVs are unique because they possess anisotropic conduction and repolarization heterogeneity allowing reentrant conduction to occur [18, 19]...
    • ...Using high-resolution optical mapping, reentry within the PV has been demonstrated and acts as a focal driver to sustain and initiate AF. Thus, reentry has been implicated as a putative mechanism in both multicircuit reentry within the atria as well as focal activity triggering AF within the PV [18]...

    Kevin J. Makati, et al. Advances in mechanisms of atrial fibrillation: structural remodeling, ...

    • ...This result is consistent with that of Arora et al. [1] who showed that focal excitation was seen from the endocardial surface of the left atrium near the PV ostium in the presence of isoproterenol...

    Masamichi Hirose, et al. Mechanisms of atrial tachyarrhythmiainduction in a canine model of aut...

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