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Extracranial internal carotid arterial disease in children with sickle cell anemia

Extracranial internal carotid arterial disease in children with sickle cell anemia,10.3324/haematol.2010.022624,Haematologica-the Hematology Journal,C

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Extracranial internal carotid arterial disease in children with sickle cell anemia   (Citations: 1)
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Background Sickle cell anemia is one of the commonest causes of stroke in children. It is usually, but not always, associated with intracranial vasculopathy. We have assessed the value of ultrasound screening for extracranial internal carotid artery disease. Design and Methods Using Doppler ultrasound scanning, we assessed peak systolic blood velocity, tortuosity and stenosis in the extracranial internal carotid arteries of 236 children with sickle cell anemia. Seventeen of the children had previously had a stroke. All measurements were performed as part of routine clinical care. Results The median extracranial internal carotid artery velocity was 148cm/s (5 th centile 84, 95 th centile 236). Higher velocities were significantly correlated with younger age, higher white blood cell counts and higher rates of hemolysis. Fourteen (5.9%) had tortuous extracranial internal carotid arteries and 13 (5.4%) had stenosis or occlusion. None of the children with tortuous vessels but 8 of those with stenosis had previously had a stroke; the presence of stenosis was strongly associated with overt clinical stroke (OR 35.9, 95% C.I. 9.77-132, P<0.001). In 6 chil - dren, extracranial stenosis was part of extensive intracranial vasculopathy, but in 2 there was no evidence of intracranial disease. Stenosis seemed to be more common in older children. Conclusions Extracranial internal carotid artery stenosis is strongly associated with stroke in children with sickle cell anemia, and may explain some cases of stroke without overt intracranial vasculopa - thy. Doppler ultrasound scanning of extracranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would other - wise be missed. The value of extracranial internal carotid artery scanning should be studied prospectively. ABSTRACT Original Articles
Journal: Haematologica-the Hematology Journal , vol. 95, no. 8, pp. 1287-1292, 2010
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