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Targeting breast cancer stem cells: fishing season open!

Targeting breast cancer stem cells: fishing season open!,10.1186/bcr2636,Breast Cancer Research,Christophe Ginestier,Emmanuelle Charafe-Jauffret,Danie

Targeting breast cancer stem cells: fishing season open!  
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ABSTRACT: Studies describing the tumor as a hierarchically organized cell population have changed the classical oncogenesis view and propose new therapeutic strategies. Cancer stem cells (CSCs) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cancer cure. A large research effort is now aiming to develop drugs targeting CSCs, based either on a priori understanding of key pathways regulating CSC biology or on high-throughput screening to identify novel targets and compounds.
Journal: Breast Cancer Research - BREAST CANCER RES , vol. 12, no. 5, pp. 312-2, 2010
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