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The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus

The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in

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The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus (Citations: 2)


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The purpose of this study was to compare the effects of 3 different modalities of exercise on metabolic control, insulin resistance, inflammatory markers, adipocytokines, and tissue expression of insulin receptor substrate (IRS)–1 after 12 weeks of training among patients with type 2 diabetes mellitus. Forty-eight patients with type 2 diabetes mellitus were randomly assigned to 4 groups of training (3 times a week, 60 minutes per session): aerobic group (n = 12), resistance group (n = 12), combined (aerobic and resistance) group (n = 12), and control group (n = 12). Fasting and postprandial blood glucose, glycated hemoglobin, lipid profile, insulin resistance index (homeostasis model assessment of insulin resistance), adipocytokines (adiponectin, visfatin, and resistin), tumor necrosis factor, interleukin, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline and at the end of the study. Patients also underwent a muscle microbiopsy before and after training to quantify IRS-1 expression. All 4 groups displayed decreases in blood pressure, fasting plasma glucose, postprandial plasma glucose, lipid profile, and hs-CRP (P < .05); and there was no difference across the groups. After training, the IRS-1 expression increased by 65% in the resistance group (P < .05) and by 90% in the combined group (P < .01). Exercise training favorably affects glycemic parameters, lipid profile, blood pressure, and hs-CRP. In addition, resistance and combined training can increase IRS-1 expression.

Journal: Metabolism-clinical and Experimental - METABOLISM , vol. 60, no. 9, pp. 1244-1252, 2011

DOI: 10.1016/j.metabol.2011.01.006

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Citation Context (2)

- ...
  
  In both ‘at-risk’ and ‘cases’, moderate-high LTPA was inversely associated with FMI expression, consistent with studies, which have shown improvements in fat mass and insulin regulation across the metabolic disease continuu...
M T Haren, et al. Proximal correlates of metabolic phenotypes during ‘at-risk’ and ‘case...
- ...Several studies show that exercise training decreases insulin resistance and improves glucose control and diabetes, concomitantly increasing the adiponectin levels and the protein expression of insulin receptors in the skeletal muscle [18,38-40]...
Fábio S Lira, et al. Exercise training improves sleep pattern and metabolic profile in elde...

References (1)

The properties of gases and liquids (Citations: 4892)

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Keywords (17)

The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in

Citation Context (2)

M T Haren, et al. Proximal correlates of metabolic phenotypes during ‘at-risk’ and ‘case...

Fábio S Lira, et al. Exercise training improves sleep pattern and metabolic profile in elde...

References (1)

The properties of gases and liquids (Citations: 4892)

Citations (2)

Proximal correlates of metabolic phenotypes during ‘at-risk’ and ‘case’ stages of the metabolic disease continuum

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner


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