Top publications in cell biology 1–100 of 354,136 results
Publications Citations  
1
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY (1963) 9541
2
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION (1959) 8037
3
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation (1992) 4654
4
A series of normal stages in the development of the chick embryo (1951) 4080
5
IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODS (1961) 3853
6
Integrins: Versatility, modulation, and signaling in cell adhesion (1992) 3698
7
A genetic model for colorectal tumorigenesis (1990) 3578
8
Cell Death: The Significance of Apoptosis (1980) 3028
9
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm (1994) 2973
10
Nutrient requirements of suspension cultures of soybean root cells (1968) 2931
11
Cytochrome c and dATP-Dependent Formation of Apaf1/Caspase9 Complex Initiates an Apoptotic Protease Cascade (1997) 2782
12
p53, the Cellular Gatekeeper for Growth and Division (1997) 2780
13
Simple technique for quantitation of low levels of DNA damage in individual cells (1988) 2644
14
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis (1996) 2512
15
WAF1, a potential mediator of p53 tumor suppression (1993) 2505
16
Apoptosis by Death Factor (1997) 2363
17
The nuclear receptor superfamily: The second decade (1995) 2177
18
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery (1997) 2171
19
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors (2006) 2156
20
The neural basis of drug craving: An incentive-sensitization theory of addiction (1993) 2147
21
The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells (1982) 2045
22
A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY (1965) 1918
23
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors (2007) 1835
24
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c (1996) 1825
25
Lessons from Hereditary Colorectal Cancer (1996) 1819
26
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor (1999) 1811
27
MicroRNAs (2004) 1803
28
The retinoblastoma protein and cell cycle control (1995) 1788
29
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets (2005) 1725
30
Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death (1993) 1721
31
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation (1998) 1701
32
Pathogen Recognition and Innate Immunity (2006) 1676
33
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 (1993) 1664
34
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation (1995) 1662
35
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis (1998) 1652
36
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density (1997) 1615
37
Lipid rafts and signal transduction (2000) 1563
38
STAINING OF TISSUE SECTIONS FOR ELECTRON MICROSCOPY WITH HEAVY METALS (1958) 1545
39
Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth (1997) 1531
40
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors (1998) 1495
41
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases (1993) 1493
42
A simple technique for demonstrating centromeric heterochromatin (1972) 1442
43
Bcl2 functions in an antioxidant pathway to prevent apoptosis (1993) 1434
44
Integrins: A family of cell surface receptors (1987) 1420
45
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue (1980) 1418
46
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia (1995) 1379
47
CYTOCHEMISTRY AND ELECTRON MICROSCOPY: The Preservation of Cellular Ultrastructure and Enzymatic Activity by Aldehyde Fixation (1963) 1374
48
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior (1998) 1374
49
Functional discovery via a compendium of expression profiles (2000) 1361
50
ABC Transporters: From Microorganisms to Man (1992) 1358
51
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus (2003) 1344
52
Cell Signaling by Receptor Tyrosine Kinases (2000) 1343
53
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes (1986) 1338
54
Interleukin10deficient mice develop chronic enterocolitis (1993) 1322
55
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain (1999) 1318
56
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line (1988) 1296
57
Signal Transduction by the JNK Group of MAP Kinases (2000) 1288
58
The limited in vitro lifetime of human diploid cell strains*1, *2 (1965) 1278
59
Chromatin Modifications and Their Function (2007) 1276
60
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling (1992) 1268
61
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation (1997) 1252
62
Cell Migration: A Physically Integrated Molecular Process (1996) 1251
63
FLICE, A Novel FADD-Homologous ICE/CED3–like Protease, Is Recruited to the CD95 (Fas/APO1) Death-Inducing Signaling Complex (1996) 1244
64
Dystrophin: The protein product of the duchenne muscular dystrophy locus (1987) 1242
65
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors (1992) 1238
66
CNS stem cells express a new class of intermediate filament protein (1990) 1233
67
Biology of Natural Killer Cells (1989) 1217
68
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes (1991) 1216
69
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents (1993) 1213
70
Identification and expression cloning of a leptin receptor, OB-R (1995) 1209
71
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation (1991) 1208
72
A rapid method for the isolation of functional thymus-derived murine lymphocytes (1973) 1206
73
The scanning model for translation: an update (1989) 1196
74
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition (2000) 1193
75
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16 INK4a (1997) 1190
76
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell (2001) 1187
77
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis (1996) 1186
78
A conserved AU sequence from the 3? untranslated region of GM-CSF mRNA mediates selective mRNA degradation (1986) 1183
79
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis (1991) 1177
80
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death (1993) 1165
81
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family (1993) 1159
82
Chromosome preparations of leukocytes cultured from human peripheral blood (1960) 1152
83
The RXR heterodimers and orphan receptors (1995) 1149
84
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity (1991) 1144
85
A genome-wide transcriptional analysis of the mitotic cell cycle (1998) 1135
86
Nitric oxide synthases: Roles, tolls, and controls (1994) 1132
87
FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES (1998) 1132
88
Prediction of Mammalian MicroRNA Targets (2003) 1121
89
JNK1: A protein kinase stimulated by UV light and HaRas that binds and phosphorylates the c-Jun activation domain (1994) 1118
90
Untangling the ErbB signalling network (2001) 1111
91
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments (2003) 1107
92
HOW MATRIX METALLOPROTEINASES REGULATE CELL BEHAVIOR (2001) 1105
93
Homozygous Defect in HIV1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV1 Infection (1996) 1100
94
H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response (1994) 1094
95
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia (1992) 1091
96
Apaf1, a Human Protein Homologous to C. elegans CED4, Participates in Cytochrome c–Dependent Activation of Caspase3 (1997) 1089
97
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface (1992) 1089
98
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality (1992) 1086
99
Programmed Cell Death in Animal Development (1997) 1085
100
Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts (1997) 1079